Hoehe M, 1988. Influence on the menstrual cycle on neuroendocrine and behavioral responses to an opiate agonist in humans: preliminary results. Psychoneuroendocrinology
enzalutamide will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to some decrease in fentanyl plasma concentrations, deficiency of efficacy or, potentially, progress of a withdrawal syndrome in the client that has formulated Bodily dependence to fentanyl.
bremelanotide will lessen the level or effect of fentanyl by Other (see comment). Stay away from or Use Alternate Drug. Bremelanotide may well slow gastric emptying and potentially decreases the rate and extent of absorption of concomitantly administered oral medications.
olanzapine/samidorphan decreases effects of fentanyl by pharmacodynamic antagonism. Contraindicated. Samidorphan elicits opioid antagonistic effects and improves risk of precipitating acute opioid withdrawal in patients dependent on opioids.
Evaluate Each and every client’s risk for opioid addiction, abuse, or misuse ahead of prescribing opioid and monitor; risks are elevated in patients with a personal or loved ones history of substance abuse (such as drug or alcohol abuse or addiction) or mental illness (eg, significant depression); potential for these risks shouldn't prevent good management of pain in almost any given client; patients at improved risk can be prescribed opioids, but use in this kind of patients necessitates intense counseling about risks and correct use of opioid sulfate along with intense monitoring for signs of addiction, abuse, and misuse; prescribe the drug in smallest suitable quantity and suggest affected individual on good disposal of unused drug
buprenorphine decreases effects of fentanyl by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics could cut down fentanyl's analgesic effect and possibly precipitate withdrawal symptoms.
diazepam intranasal and fentanyl equally enhance sedation. Stay away from or Use Alternate Drug. Restrict use to patients for whom substitute treatment options are insufficient
Seek the advice of cardiologist if considering treatment. Coadministration of ponesimod with drugs that reduce HR may have additive effects on decreasing HR and will generally not be initiated in these patients.
fentanyl will lower the fentanyl for pain after surgery level or effect of prasugrel by inhibition of GI absorption. Applies only to oral form of equally agents. Modify Therapy/Monitor Intently. Coadministration of opioid agonists delay and decrease the absorption of prasugrel?
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mobocertinib will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. If use is unavoidable, raise CYP3A4 substrate dosage in accordance with its prescribing information.
phenelzine will increase toxicity of fentanyl by Other (see comment). Contraindicated. Comment: Avoid fentanyl in patients who have to have concomitant administration MAOIs, or within 14 times of stopping an MAOI. Intense and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics.
In patients who might be prone to intracranial effects of CO2 retention (e.g., Individuals with evidence of elevated intracranial pressure or Mind tumors), therapy may possibly lessen respiratory drive, and resultant CO2 retention can even more boost intracranial pressure; keep track of such patients for signs of sedation and respiratory depression, specially when initiating therapy; opioids may possibly obscure clinical program inside of a individual with a head damage; steer clear of the use in patients with impaired consciousness or coma
If coadministration of CYP3A4 inhibitors with fentanyl is essential, keep track of patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose adjustments until eventually stable drug effects are accomplished.